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" April 25, 2003 -- Timely research for the start of hay fever season: Despite their higher cost, the newer, so-called "second generation" of more expensive "nonsedating" prescription antihistamines may be no more effective at preventing fatigue and memory lapses than older over-the-counter formulas such as Benadryl.

So concludes a new study published in the current issue of Journal of Allergy and Clinical Immunology in which researchers compared 18 previous trials investigating antihistamine-caused sedation levels in 1,500 people between ages 8 and 81.

Benzodiazepines, such as diazepam (Valium), chlordiazepoxide HCl (Librium), and alprazolam (Xanax), which can be prescribed to treat anxiety, acute stress reactions, and panic attacks; the more relaxing benzodiazepines, such as triazolam (Halcion) and estazolam (Pro Som) can be prescribed for short-term treatment of sleep disorders.

In higher doses, some CNS depressants can be used as general anesthetics.

That means you can control your symptoms with only 1 or 2 doses each day compared with older medications, which usually require doses every 4 to 6 hours to maintain their effectiveness.

The newer antihistamines are available only by prescription.

The difference between them is really blurred." "Under some circumstances, the nonsedating formulas do cause sedation and in some cases, these sedating formulas do not," he tells Web MD.

"In some studies we reviewed, some people actually experienced more sedation with the newer, nonsedating formulas than with the older, sedating products.

The advantage of the Borneo strains is that they have a tremendously low side-effect aspect in contrast to other strains of its type.Neurotransmitters are brain chemicals that conduct communication between brain cells. Although the different types of CNS depressants each work in their own way, ultimately it is through their ability to increase GABA activity that they produce a relaxing effect that is beneficial to those suffering from anxiety or sleep disorders.Among the medications that are commonly prescribed for these purposes are the following: Barbiturates, such as mephobarbital (Mebaral) and pentobarbital sodium (Nembutal), which are helpful in treating anxiety, tension, and sleep disorders.This content has not been reviewed within the past year and may not represent Web MD's most up-to-date information.To find the most current information, please enter your topic of interest into our search box.